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Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

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Innovative Environment: Help to pioneer advancements in cancer immunotherapy.

Collaborative Culture: Be part of a diverse team dedicated to your professional growth.

Global Impact: Contribute to therapies that make a lasting impact on patients globally.

We are seeking an SAP S/4HANA Manufacturing Systems Specialistto support our US Computer Systems Validation team. The SAP S/4HANA Manufacturing Systems Specialist is responsible for configuring, supporting, and optimizing SAP S/4HANA manufacturing solutions in a regulated (GxP) environment. This role partners closely with manufacturing business users, SAP developers, engineering, and validation teams to deliver compliant, efficient, and scalable manufacturing processes.

The position requires a strong combination of SAP manufacturing configuration expertise, Engineering Change Management (ECM) experience, technical collaboration skills, and experience working within validated SAP landscapes.

FLSA Classification: Salary, Exempt

Schedule: 8:00 AM – 5:00 PM; Monday to Friday; On-site

Reports to: ERP Manager

Location: 13203 Murphy Road Suite 100 Stafford, TX 77477

What You’ll Do:

As an SAP S/4HANA Manufacturing Systems Specialist, you will play a key role in supporting our Computer Systems Validation team:

Configure and support SAP S/4HANA manufacturing processes, primarily with integration to Extended Warehouse Management (EWM), Materials Management (MM) and Quality Management (QM).

Maintain and support manufacturing master data including BOMs, routings, work centers, production versions, and production orders.

Support Engineering Change Management (ECM) processes, including configuration and management of engineering changes impacting BOMs, routings, and production data.

Ensure engineering changes are properly assessed, documented, approved, and implemented in SAP in alignment with change control and validation requirements.

Translate manufacturing and engineering business requirements into clear functional and technical specifications.

Collaborate with SAP developers on custom developments, enhancements, interfaces, and integrations related to manufacturing and ECM processes.

Support SAP Computer System Validation (CSV) activities, including impact assessments, testing, and documentation in compliance with GxP requirements.

Partner with validation and quality teams to ensure all system and engineering changes meet regulatory and audit standards.

Provide production support, issue resolution, and root cause analysis for manufacturing- and engineering-related SAP issues.

Support system upgrades, enhancements, and continuous improvement initiatives within SAP S/4HANA manufacturing.

Required Experience and Education:

Bachelor’s degree in IT, Engineering, Manufacturing, or a related field, or equivalent experience.

Minimum of 5 years of hands-on experience working in SAP S/4HANA environments

Hands-on experience configuring SAP S/4HANA manufacturing solutions.

Experience supporting Engineering Change Management (ECM) processes and Master data Updates within SAP.

Experience working with SAP developers on technical solutions and system integrations.

Experience supporting SAP systems in regulated (GxP) environments with validation requirements.

Strong understanding of end-to-end manufacturing and engineering processes.

Preferred Experience and Education: 

Experience in pharmaceutical, biotech, medical device, or other regulated manufacturing industries.

Experience with SAP ECC to S/4HANA manufacturing migrations.

Knowledge of shop floor integration, MES, or manufacturing execution systems.

Competencies

Strong SAP S/4HANA manufacturing functional and technical expertise

Solid understandi

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SAP S/4HANA Manufacturing Systems Specialist